Thursday afternoon, May 28
Bioscience Research Building
Registration 1:00 PM – 4:00 PM - Colonnade
Opening remarks: 3:30 – 4 pm - Lecture Hall, RM 1101
Dr. Norma Allewell, Dean of College of Chemical and Life Sciences, UMCP
Davies Symposium: 4 – 6:20 pm (4 speakers; 30 minutes plus 5 minutes discussion)
Session chair: Fred Dyda
Robert Stroud (UCSF)
Maxwell's Demons and 'r Breniniaethau chan Cymru
Brian Matthews (U. Oregon)
Holey proteins and holy people
Alexander Wlodawer (NCI / NIH)
Back to the future: Or, how I finally decided to follow in David’s footsteps by studying antibodies
David Davies (NIDDK / NIH)
Fifty years of protein structure: from myoglobin to the innate immune system
Banquet and evening session: 6:30 to 10 pm
Adele H. Stamp Student Union, Grand Ballroom, RM 1206
Session Chair: Peter Sun
Peter Sun (NIAID / NIH)
Jessica Bell (VCU)
Steven Sheriff (Bristol-Myers Squibb)
Sandra Smith-Gill (NCI / NIH)
Friday morning, May 29
Bioscience Research Building
Breakfast 7:30 – 8:30 am - Colonnade
Session I: 8:30 – 10:35 am – Lecture Hall, RM 1101
Session chair: Jim Hurley
Trafficking and signalling (5 speakers; 20 minutes plus 5 minutes discussion)
John Sondek (UNC)
General and versatile regulation of phospholipase C isozymes
Adriana Rojas (NIDDK / NIH)
Crystallographic studies of sorting signal recognition by clathrin adaptor proteins
Steven Sheriff (Bristol-Myers Squibb)
The structures of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different conformations
Daniel Leahy (JHU)
The influence of structure on the understanding and design of ErbB-targeted drugs
Peter Kwong (VRC / NIH)
From antibody to vaccine: a structure-based paradigm for HIV-1
10:35 – 11 am - Colonnade
Coffee
Session II: 11 am – 1:05 pm – Lecture Hall, RM 1101
Session chair: Lorena Beese
Nucleic acids and beyond (5 speakers; 20 minutes plus 5 minutes discussion)
Cynthia Wolberger (JHU)
The unusual chemistry of Sir2 enzymes
Xinhua Ji (NCI / NIH)
How dicer dices
Michael Hast (Duke)
Structure and inhibition of protein prenyltransferases from human pathogens
Andres Larrea (NIEHS)
Scrunching during DNA repair synthesis
Nicole LaRonde-LeBlanc (UMd)
Ammonia tunneling and active site coupling in glutamine-dependent NAD+ synthetase
Friday afternoon
Lunch 1:05 - 2:30 pm – Colonnade
Session III: 2:30 – 4:50 pm - Lecture Hall, RM 1101
Session chair: Wei Yang
Methods (4 speakers; 30 minutes plus 5 minutes discussion)
Paul Emsley (York, UK)
Coot
Paul Adams (LBNL)
PHENIX
Janet Smith (U Mich)
Microcrystallography for crystals large and small
Zbyszek Dauter (NCI / NIH)
Unusual OD-twinning in crystals of a fluorescent protein
Business meeting: 5:00 – 5:15 pm – Dean’s Conference Room, RM 3101
Business meeting to decide next year’s MACA host
Poster and Exhibitor Session: 5:30 – 7:30 pm – Seminar Room, RM 1103 and Colonnade
Refreshments served
Saturday morning, May 30
Bioscience Research Building
Breakfast 7:30 – 8:30 am - Colonnade
Session IV: 8:30 am – 12 pm – Lecture Hall, RM 1101
Session chair: Susan Buchanan
Breakthroughs and applications (7 speakers; 20 minutes plus 5 minutes discussion)
Joseph Ferrara (Rigaku)
Revolutionary products from visionary insights
Matt Benning (Bruker)
Advances in hardware and software tools for macromolecular crystallography
Jason McLellan (VRC / NIH)
Large-scale transient transfection of mammalian cells
Zygmunt Derewenda (UVa)
A microscopic view of protein crystallization
10:10 – 10:40 am
Coffee - Colonnade
Matt Warkentin (Cornell)
Slow cooling of protein crystals: A new approach for low- and variable temperature
crystallographic data collection
Andrea Moon (JHU)
A Synergistic Approach to Problematic Protein Crystallography: Affinity Tag Crystallization
and Surface Entropy Reduction
Jinghua Lu (NIAID / NIH)
Structural recognition and functional activation by pentraxins
Lunch: 12 pm (box lunch provided) - Colonnade